Protease mediated drug delivery offers such a possibility. There is some evidence that particles less than 1. SLNs have another advantage of allowing autoclave sterilization, a necessary step towards formulation of ocular preparations. Inventor ; Eddington, David T. Many important drugs such as insulin, and erythropoietin are smaller or comparable in size, making the PWs attractive for transdermal drug delivery. Delivery of these molecules to specific areas within the body can be achieved, which will reduce systemic side effects and allow for more efficient use of the drug. Pharmaceutical Technology International ; 1:

Ion-Responsive Drug Delivery Systems. The functions of ion-responsive drug delivery systems were categorized to controlled drug release, site-specific drug release, in situ gelation, prolonged retention at the target sites, and enhancement of drug permeation. Microfabrication will continue to offer new, alternative solutions for the development of smart, advanced drug delivery systems. The revised model showed high degree of predictability and optimisation reliability and therefore was successful in developing an ODT formulation with optimised properties that were able deliver enteric coated multiparticulates of omeprazole without compromising their functionality. The void spaces between the primary particles are occupied by the binder solution added and form as lens-like rings by liquid bridges at contact points of two adjacent particles and results in pendular agglomerates.

Drugs used in disease treatment can cause damage to both malignant and normal tissue.

This is likely because of the increased solubility of theophylline and the intrinsic properties of the Surelease films. Friability and hardness helps to withstand subsequent coating and high attrition during coating.

In particular, fabrication methods along with compatible materials have been successfully designed to produce multifunctional, highly effective drug delivery systems. Conventional drug delivery may make drugs inactive or reduce their potency as they may be hydrolyzed or degraded enzymatically and are rapidly excreted through the multparticulate system resulting in suboptimal concentration of drugs at the desired site. Surface roughness is analyzed by fractal geometry of particle obtained by microscopy with image analysis and SEM.


Htesis drug delivery remains challenging because of the complex nature and structure of the eye. Ionresponsive drug delivery is available to design the unique dosage formulations which provide optimized drug therapy with effective, safe and convenient dosing of drugs. Drug entrapment and drug release from dendrimers can be controlled by modifying dendrimer surfaces and generations.

multiparticulate drug delivery system thesis

Druv placebo beads and drug beads were blended together and compacted on an instrumented Stokes B2 rotary tablet press. Multi-kinetic release of benznidazole-loaded multiparticulate drug delivery systems based on polymethacrylate interpolyelectrolyte complexes.

multiparticulate drug delivery system thesis

Nanotechnology is expected to have an impact on all industries including semiconductors, manufacturing, and biotechnology. Therefore, the most exploited targets for cancer drug delivery are; cancer cell enzymes, heat shock protein 90 HSP90multi- drug resistance MDR proteins, angiogenesis, apoptosis and cell membrane receptors e.

The former Apparatus I with an inlet at the top for introducing droplets and the droplets settle at the bottom of the column as the density of the matrix droplet is more than the liquid column Figure In this technique, liquid in required amount is added prior to or during agitation stage to finely divided particles and this mass under continuous rolling or tumbling motion results in spherical particles.

Multiparticulate oral drug delivery systems have acquired a center stage in the arena of pharmaceutical research and development; thus provide greater opportunities in extending the first step of future pharmaceutical development.

Pelletization techniques, TTC Workshop. Promising concepts are the solid dosage pen and drug -loaded oral films which can be cut in individual sections enabling freely selectable doses.

Ocular drug delivery to the posterior segment of the eye can be accomplished by invasive drug injections into different tissues durg the eye and noninvasive topical treatment. Pellets with specific release profiles are compressed to tablets. Thus immune cells can be exploited as trojan horses for drug delivery.


multiparticulate drug delivery: Topics by

Administration of the formulations via oral, ophthalmic, transdermal, and nasal routes has showed significant advantages in the recent literatures. Dependent variables considered were disintegration time DT -Y 1sphericity-Y 2and percent drug release-Y 3. In preschool children, small-volume spacers perform better than large-volume spacers. Of these two methods, the sputtered Pt-coated metal foam has a higher pumping rate; it also has a comparable recombination rate when compared to the electroplated Pt-coated metal foam.

MRI provides a means to non-invasively and continuously monitor ocular drug-delivery systems with a contrast agent or compound labeled with a contrast agent.

multiparticulate drug delivery system thesis

Neutral cores coated with drug and one or more rate controlling polymers to attain drug release in a predetermined manner for once a day release profile.

Journal of Pharmaceutical Sciences ; The intracellular route appears to be the most likely pathway of drug delivery through the SC.

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Multiple regression showed that ketoprofen release from pellet-containing thedis is predominantly influenced by pellet content, hardness, friability, and disintegration time.

Polylactic-co-glycolic acid PLGA is one of the extensively researched synthetic biodegradable polymers due to its favorable properties. However, the cochlea is a particularly challenging target for drug therapy, and new technologies will be required to provide safe and efficacious delivery of these compounds. Dry powder layering of nuclei. Nanotechnology is expected to revolutionize ocular drug delivery. In this review, we highlight the main features, advantages, drawbacks and recent developments of nanostructures for protein encapsulation, such as nanoemulsions, liposomes, polymersomes, single-protein nanocapsules and hydrogel nanoparticles.

Mucoadhesive drug delivery systems. Dendrimer nanotechnology, due to its multifunctional ability, has the potential to create next generation nanodevices.